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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1954851Generated: November 4, 2026

3-(4-Fluorophenyl)-2-propenoic acid → 3-(4-Fluorophenyl)propionic acid

https://huagongshe.com/reaction/1954851

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Fluorophenyl)-2-propenoic acidHCID 98070—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
Product3-(4-Fluorophenyl)propionic acidHCID 13630291%

Reaction Steps

A mixture of 4-fluorocinnamic acid (300.0 g, 1.8 mol, Aldrich) and 5% palladium on carbon (9.0 g) in ethanol (3 L) was hydrogenated at atmospheric pressure and room temperature of 4.5 h. The mixture was filtered through Celite (diatomaceous earth) and the filtrate was concentrated in vacuo to give 275.1 g (91%) of 3-(4-fluorophenyl)propionic acid as a white solid, m.p., 86-88° C.;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06124284
Source datasetuspto-grants-2000_09
ORD IDord-edcb6a4d1e2844c7900031d5bac2d731
Source noteuspto-grants-2000_09