HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(4-Fluorophenyl)propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(4-Fluorophenyl)propionic acid | HCID 136302 | — |
| Product | 3-(4-Fluorophenyl)propionyl chloride | HCID 21964258 | 96.3% |
Reaction Steps
A mixture of 3-(4-fluorophenyl)propionic acid (275.1 g, 1.6 mol) and thionyl chloride (300 mL, 4.1 mol) was heated to reflux for 3 h, cooled to room temperature and distilled under aspirator vacuum to give 287.6 g (96%) of 3-(4-fluorophenyl)propionyl chloride as a pale pink oil, b.p., 120-122° C./15 mm Hg;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124284 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-99ea643a165f44458e75d1d652af2e01 |
| Source note | uspto-grants-2000_09 |