Oxalyl chloride → (E)-2-(6-fluoro-1-indanylidene)acetyl chloride

Participants

Reaction Steps

An ice-cold, stirred suspension of (E)-2-(6-fluoro-1-indanylidene)acetic acid (384 mg, 2 mmol) in benzene (10 mL) was treated with oxalyl chloride (761 mg, 6 mmol) and allowed to warm to room temperature during 1.5 h. The resulting yellow solution was concentrated in vacuo to give (E)-2-(6-fluoro-1-indanylidene)acetyl chloride as a pale yellow solid (421 mg, 100%), m.p., 97-99° C.;

Provenance & Evidence