Aluminum(III) Chloride → 4,6-difluoro-2,3-dihydro-1H-inden-1-one

To a mixture of 3-(2,4-difluorophenyl) propanoic acid (28.7 g, 0.15 mol) and dimethylformamide (5 drops) at ambient temperature was added dropwise oxalyl chloride (50 mL, Aldrich). The mixture was stirred at ambient temperature for 18 h. The excess oxalyl chloride was removed by distillation in vacuo to give 3-(2,4-difluorophenyl)propionyl chloride. A solution of the 3-(2,4-difluorophenyl)propionyl chloride in dichloromethane (300 mL) was added dropwise to a mixture of aluminum chloride (23.4 g, 0.18 mol, Aldrich) in dichloromethane (300 mL) at ice bath temperature. After the addition was completed, the mixture was refluxed for 3.5 h and allowed to come to ambient temperature overnight. The reaction mixture was poured into ice water (1500 mL), the two phases were separated and the aqueous phase was extracted with dichloromethane. The combined organic phase was washed successively with 0.1N aqueous sodium hydroxide and saturated sodium chloride solution, dried over sodium sulfate and concentrated in vacuo to give 21.7 g of crude 4.6-difluoro-1-indanone. Chromatography on silica gel with hexanes: dichloromethane (3:1) as eluent gave 10.1 g of a light yellow solid. Recrystallization of 0.5 g from acetone: water mixture gave 0.2 g of 4,6-difluoro-1-indanone as a white solid: mp 97-99° C.; NMR (CDCl3): d 7.02-7.27 (m, 2H), 3.12 (t, 2H), 2.76 (m, 2H).

1. additionAfter the addition
2. temperaturethe mixture was refluxed for 3.5 h
3. customthe two phases were separated
4. extractionthe aqueous phase was extracted with dichloromethane
5. washThe combined organic phase was washed successively with 0.1N aqueous sodium hydroxide and saturated sodium chloride solution
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated in vacuo

ORD record

ord-869f6995e6c54e819c75b3879efa5d7d

Source dataset

uspto-grants-2000_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06124284