HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (E)-2-(4,6-difluoro-1-indanylidene)acetic acid | HCID 10976722 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride | HCID 10977254 | — |
Reaction Steps
A suspension of (E)-2-(4,6-difluoro-1-indanylidene)acetic Acid (5.49 g, 0.026 mol) in a mixture of dichloromethane: dimethylformamide (50 mL: 5 drops) was treated with oxalyl chloride (6.6 g 0.052 mol, Aldrich) and allowed to stir at ambient temperature for 18 h. The resulting solution was concentrated in vacuo and the residue used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124284 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-e3fdb48fe6554226bde281be60a6501c |
| Source note | uspto-grants-2000_09 |