化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 3-(2-fluorophenyl)prop-2-enoate → Ethyl 3-(2-fluorophenyl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(2-fluorophenyl)prop-2-enoate | HCID 590919 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Platinum oxide monohydrate | HCID 86587499 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 3-(2-fluorophenyl)propanoate | HCID 14879014 | 99% |
反応手順
A mixture of ethyl 2-fluorocinnamate (29.25 g, 0.176 mol) and platinum oxide hydrate (0.25, EM Scientific) in 95% ethanol (150 mL) was placed on a Parr hydrogenation apparatus and shaken under 2-4 atm at hydrogen pressure. After the appropriate amount of hydrogen was consumed, the catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give 29.39 g (99%) of crude ethyl 3-(2-fluorophenyl)propionate. This material was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06124284 |
| 出典データセット | uspto-grants-2000_09 |
| ORD ID | ord-3f6994e5961c472785da87f605f3ac44 |
| 出典メモ | uspto-grants-2000_09 |