(E)-2-(4,6-difluoro-1-indanylidene)acetic acid → (E)-2-(4-fluoro-1-indanylidene)acetyl Chloride

HRID 1954877Notes

Reaction equation

HRID 1954877 reaction equation
[F:1][C:2]1[CH:10]=[C:9](F)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:15])=[O:14].FC1C=C(F)C=C2C=1CC/C/2=C\C(O)=O>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:15])=[O:14]

Participants

3

Reactant 2

HCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acidHCID 10977254(E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

Product 1

HCID 23293683(E)-2-(4-fluoro-1-indanylidene)acetyl Chloride

Procedure

This compound was prepared in a similar manner to (E)-2-(4,6-difluoro-1-indanylidene)acetyl chloride in Example 5f by substituting (E)-2-(4-fluoro-1-indanylidene)acetic acid (5.77 g, 0.03 mol) for (E)-2-(4,6-difluoro-1-indanylidene)acetic acid. The resulting solution was concentrated in vacuo, and the residue was used without further purification.

Workup

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customthe residue was used without further purification

Sources & evidence

ORD record
ord-59fa4e41488045dbb7d7eb0f6afca2ba
Source dataset
uspto-grants-2000_09
Patent number
US06124284

Reaction notes

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