(E)-2-(4,6-difluoro-1-indanylidene)acetic acid → (E)-2-(5-fluoro-1-indanylidene)acetyl Chloride

HRID 1954880Notes

Reaction equation

HRID 1954880 reaction equation
F[C:2]1[CH:10]=[C:9](F)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:15])=[O:14].[F:16]C1C=C(F)C=C2C=1CC/C/2=C\C(O)=O>>[F:16][C:10]1[CH:2]=[C:3]2[C:7](=[CH:8][CH:9]=1)/[C:6](=[CH:12]/[C:13]([Cl:15])=[O:14])/[CH2:5][CH2:4]2

Participants

3

Reactant 2

HCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acidHCID 10977254(E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

Product 1

HCID 23293623(E)-2-(5-fluoro-1-indanylidene)acetyl Chloride

Procedure

This compound was prepared in a similar manner to (E)-2-(4,6-difluoro-1-indanylidene)acetyl chloride in Example 5f by substituting (E)-2-(5-fluoro-1-indanylidene)acetic acid (5.77 g, 0.03 mol) for (E)-2-(4,6-difluoro-1-indanylidene)acetic acid. The resulting solution was concentrated in vacuo, and the residue was used without further purification.

Workup

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customthe residue was used without further purification

Sources & evidence

ORD record
ord-8fcf4761d31f46b2b202001c3df4c7c2
Source dataset
uspto-grants-2000_09
Patent number
US06124284

Reaction notes

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