Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 339-34-4 | HCID 23293615 | — |
| Product | HCID 23293596 | HCID 23293596 | 101.6% |
Reaction Steps
Oxalyl chloride (46.5 g, 0.367 mol, Aldrich) was added to a solution of 3-(4-fluorophenyl)-3-methylbutyric acid (24 g, 0.122 mol) at -10° C. while protected from moisture by a nitrogen atmosphere. The stirring mixture was allowed to warm to 25° C. and was stirred for 2 h. Fractional distillation gave 26.6 g (76%) of 3-(4-fluorophenyl)-3-methylbutyryl chloride as a clear oil, b.p., 132-138° C.:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06124284 |
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| Source dataset | uspto-grants-2000_09 |
|---|
| ORD ID | ord-eb32d070338f466e887a40f267d2891d |
|---|
| Source note | uspto-grants-2000_09 |
|---|
