HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 3-(4-fluorophenyl)butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 3-(4-fluorophenyl)prop-2-enoate | HCID 367200 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Ethyl 3-(4-fluorophenyl)butyrate | HCID 11160124 | 97% |
Reaction Steps
A mixture of ethyl 4-fluorocinnamate (47.5 g, 0.228 mol) and 10% palladium on carbon (0.85 g, Aldrich) in 95% ethanol was shaken in a Parr hydrogenator under 2-3 atm of H2 pressure for 1 h. The mixture was filtered and concentrated by spin evaporation in vacuo. Fractional distillation gave 46.5 g (97%) of ethyl 3-(4-fluorophenyl)butyrate as a clear oil, b.p., 122-128° C.: c) Preparation of 3-(4-Fluorophenyl)butanoic Acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124284 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-a059715cd1ef4144b2bc029f04de0b0e |
| Source note | uspto-grants-2000_09 |