HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1954933Generated: November 2, 2026
(Diethylamino)sulfur trifluoride → BW-4030W92, (-)-
https://huagongshe.com/reaction/1954933
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | 2,4-Diamino-5-(2,3-dichlorophenyl)-6-hydroxymethylpyrimidine | HCID 18403934 | — |
| Product | BW-4030W92, (-)- | HCID 9860692 | — |
Reaction Steps
Fluorination of racemic 2,4-diamino-5-(2,3-dichlorophenyl)-6-hydroxymethyl pyrimidine can be effected using diethylaminosulphur trifluoride (DAST). That may be carried out in dichloromethane at, initially, -78° C. followed by warming to -10° C. for four and a half hours, to afford racemic 2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethyl pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06124308 |
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| Source dataset | uspto-grants-2000_09 |
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| ORD ID | ord-e64a2494219c4133a7317a4bd30a68bb |
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| Source note | uspto-grants-2000_09 |
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