2-[(6-Chloropyridin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione → 1-(6-Bromopyridin-3-yl)methanamine

HRID 1954970Notes

Reaction equation

HRID 1954970 reaction equation
[Br:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2C(=O)C3=CC=CC=C3C2=O)=[CH:4][CH:3]=1.ClC1N=CC(CN2C(=O)C3=CC=CC=C3C2=O)=CC=1>>[Br:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 143247132-[(6-Chloropyridin-3-yl)methyl]-1H-isoindole-1,3(2H)-dioneHCID 224505102-[(6-Bromo-3-pyridinyl)methyl]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 224505291-(6-Bromopyridin-3-yl)methanamine

Procedure

The reaction procedure of Reference Example 3 was repeated except that N-(6-bromo-3-pyridylmethyl)phthalimide was used in lieu of N-(6-chloro-3-pyridylmethyl)phthalimide, to give the title compound as sale yellow crystals.

Workup

  1. customThe reaction procedure of Reference Example 3

Sources & evidence

ORD record
ord-4ac0d27013314ef4b1995c6f3865182e
Source dataset
uspto-grants-2000_09
Patent number
US06124297

Reaction notes

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