HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-(2-Nitro-6-methylbenzylamino)-3-chloro-2-methylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-(chloromethyl)-1-methyl-3-nitroBenzene | HCID 12204070 | — |
| Reactant | 3-Chloroimidazo[1,2-a]pyridin-8-amine | HCID 23294176 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-(2-Nitro-6-methylbenzylamino)-3-chloro-2-methylimidazo[1,2-a]pyridine | HCID 23294163 | — |
Reaction Steps
Starting from 8-amino-3-chloroimidazo[1,2-a]pyridine (9.26 g), 6-methyl-2-nitrobenzyl chloride (10.5 g), sodium carbonate (13.7 g) and sodium iodide (8.55 g) in acetone (380 ml) according to the procedure indicated in Example B1 gives, after chromatography on silica gel (eluent: toluene/dioxane=20:1) and crystallization from ethyl acetate/cyclohexane, 10.6 g (63%) of the title compound of m.p. 142-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124313 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-b7262dd9aca44a7d84425fd8463c6f78 |
| Source note | uspto-grants-2000_09 |