HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-(2-tert-Butoxycarbonylamino-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Tert-butoxycarbonylamino-6-methylbenzylchloride | HCID 14368482 | — |
| Reactant | 2,3-Dimethylimidazo[1,2-a]pyridin-8-amine | HCID 21873980 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-(2-tert-Butoxycarbonylamino-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine | HCID 23287297 | — |
Reaction Steps
Starting from 8-amino-2,3-dimethylimidazo[1,2-a]pyridine (4.8 g), 2-tert-butoxycarbonylamino-6-methylbenzyl chloride (9.2 g), sodium iodide (5.5 g) and sodium carbonate (8.0 g) in acetone (250 ml) analogously using the process of Example B1 gives, after chromatography on silica gel (eluent toluene/dioxane 20:1) and recrystallization from diisopropyl ether, 7.1 g (62%) of the title compound of m.p. 149-152° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124313 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-33d577e1133040fcb3f47ece4ad2dbaf |
| Source note | uspto-grants-2000_09 |