HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-(2-tert-Butoxycarbonylamino-6-methylbenzyloxy)-2,3-dimethylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Tert-butoxycarbonylamino-6-methylbenzylchloride | HCID 14368482 | — |
| Reactant | 2,3-Dimethylimidazo[1,2-a]pyridin-8-ol | HCID 22467949 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-(2-tert-Butoxycarbonylamino-6-methylbenzyloxy)-2,3-dimethylimidazo[1,2-a]pyridine | HCID 23287296 | — |
Reaction Steps
Starting from 8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine (1.6 g), 2-tert-butoxycarbonylamino-6-methylbenzyl chloride (3.1 g), sodium iodide (1.8 g) and sodium carbonate (2.7 g) in acetone (350 ml) analogously using the process of Example B1 gives, after chromatography on silica gel (eluent toluene/dioxane 5:1) and recrystallization from cyclohexane, 3.0 g (78%) of the title compound of m.p. 128-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124313 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-8498699a36b04a7897b1db728f9bba9c |
| Source note | uspto-grants-2000_09 |