HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-(2-tert-Butoxycarbonylamino-6-methylbenzyloxy)-3-formyl-2-methylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Tert-butoxycarbonylamino-6-methylbenzylchloride | HCID 14368482 | — |
| Reactant | 3-Formyl-8-hydroxy-2-methylimidazo[1,2-a]pyridine | HCID 23294187 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-(2-tert-Butoxycarbonylamino-6-methylbenzyloxy)-3-formyl-2-methylimidazo[1,2-a]pyridine | HCID 23294162 | — |
Reaction Steps
Starting from 3-formyl-8-hydroxy-2-methylimidazo[1,2-a]pyridine (2.4 g), 2-tert-butoxycarbonylamino-6-methylbenzyl chloride (4.2 g), sodium iodide (2.5 g) and sodium carbonate (3.7 g) in acetone (400 ml) analogously using the process of Example B1 gives, after recrystallization from diisopropyl ether/ethyl acetate, 4.4 g (80%) of the title compound of m.p. 189-191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124313 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-bb9010412ef94799bef0638be7f77116 |
| Source note | uspto-grants-2000_09 |