HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-(2-Amino-6-methylbenzylamino)-3-formyl-2-methylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | HCID 23294184 | HCID 23294184 | — |
| Product | 8-(2-Amino-6-methylbenzylamino)-3-formyl-2-methylimidazo[1,2-a]pyridine | HCID 23294170 | — |
Reaction Steps
Starting from 8-(2-tert-butoxycarbonylamino-6-methylbenzylamino)-3-formyl-2-methylimidazo[1,2-a]pyridine (3.6 g), trifluoroacetic acid (15 ml) and anisole (5 ml) according to the procedure described for Example C1 (Method B) gives, after chromatography on silica gel (eluent: toluene/dioxane=9:1) and crystallization from ethyl acetate/cyclohexane, 2.3 g (76%) of the title compound of m.p. 230-234° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124313 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-b97258a394b64b42aebf9d912b7219a4 |
| Source note | uspto-grants-2000_09 |