HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propanesulfonyl chloride → {3-[(Propane-1-sulfonylamino)-methyl]-phenyl}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propanesulfonyl chloride | HCID 66279 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 2-[3-(aminomethyl)phenyl]acetate hydrochloride | HCID 21185371 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | {3-[(Propane-1-sulfonylamino)-methyl]-phenyl}-acetic acid methyl ester | HCID 53817827 | — |
Reaction Steps
Following the procedure described in Preparation 8, (3-aminomethyl-phenyl)-acetic acid methyl ester hydrochloride (603 mg, 2.80 mmol) was converted to the title sulfonamide by reaction with 1-propanesulfonyl chloride (0.375 mL) and N,N-diisopropylethylamine (2.0 mL) in dichloroethane (10 mL). 1H NMR (400 MHz, CDCl3) δ 7.35-7.22 (m, 4H), 4.60 (bs, 1H), 4.29 (s, 2H), 3.70 (s, 3H), 3.63 (s, 2H), 2.92 (t, 2H), 1.79 (m, 2H), 0.99 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124314 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-ade69e4fe15f4b079db4e15391fa8830 |
| Source note | uspto-grants-2000_09 |