Potassium Carbonate → ((5-Bromopentyl)oxy)benzene

Participants

Reaction Steps

2-Benzyl-1-(5-phenoxypentyl)piperidine hydrobromide. From a mixture of 2-benzylpiperidine hydrochloride (500 mg, 2.36 mmol), K2CO3 (652 mg, 4.72 mmol, ) and 1-bromo-5-phenoxypentane (860 mg, 3.54 mmol) in CH3CN (25 mL) there was obtained the free amine as a clear amber oil; (568 mg, 71%); 1H NMR (CDCl3), 1.15-1.90 (m, 12 H), 2.29-2.89 (m, 6 H), 3.08 (dd, J1=12.6 Hz, J2=3.3 Hz, 1 H), 3.97 (t, J=6.3 Hz, 2 H), 6.85-7.33 (m, 10 H).

Provenance & Evidence