Potassium Carbonate → 2-Benzyl-1-(2-(4-nitrophenoxy)ethyl)piperidine Hydrobromide

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Reaction Steps

2-Benzyl-1-(2-(4-nitrophenoxy)ethyl)piperidine hydrobromide. From a mixture of 2-benzylpiperidine hydrochloride (1.00 g, 4.72 mmol), K2CO3 (1.30 g, 9.44 mmol) and 1-bromo-2-(4-nitrophenoxy)ethane (1.17 g, 4.96 mmol) in CH3CN (50 mL) there was obtained the hydrobromide as a pale yellow solid (888 mg, 45%); mp 180-182° C., 1H NMR (CDCl3) 1.35-2.42 (m, 6 H), 2.75-405 (m, 7 H), 4.50-4.95 (m, 2 H), 6.95-7.37 (m, 7H), 8.15-8.26 (m, 2 H), 11.72 and 11.88 (overlapping bs, 1 H). Anal. Calcd for C20H25BrN2O3 : C, 57.01; H, 5.98: N, 6.65. Found: C, 57.16; H, 6.01; N, 6.61.

Provenance & Evidence