Water → 3-Fluoro-1-nitro-4-(1H-1,2,4-triazol-1-yl)benzene

https://huagongshe.com/reaction/1955109

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	1H-1,2,4-Triazole	HCID 9257	—
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	1,2-Difluoro-4-nitrobenzene	HCID 123053	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Product	3-Fluoro-1-nitro-4-(1H-1,2,4-triazol-1-yl)benzene	HCID 5306154	72%

Reaction Conditions

Temperature	90 °C

Reaction Steps

A solution of 5.0 g(72.4 mmol) of 1H-1,2,4-triazol and 25.22 g(144.8 mmol) of dibasic potassium phosphate in 150 mL DMSO was treated with 11.52 g(72.4 mmol) of 3,4-difluoronitrobenzene followed by warming at 90° C. for 3 h. The solution was cooled and added to 500 mL water, and the resulting white solid was collected by filtration and washed with water. The white solid obtained was dried in vacuo (60° C./10 mmHg) to afford 10.79 g(72%) of the title compound as a white solid. High Resolution Mass Spectrum: Calculated for C8H5FN4O2 : 208.0396. Found: 208.0408.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06124334
Source dataset	uspto-grants-2000_09
ORD ID	ord-4a1b9cfa8c3c49f6aa1065a4c6a0f344
Source note	uspto-grants-2000_09