反应详情

A solution of 150 mg(0.40 mmol) of the compound of Example 17 in 10 mL 1:1 THF-methanol was treated with 15 mg(0.4 mmol) of sodium borohydride followed by stirring at ambient temperature for 18 h. The mixture was concentrated in vacuo, dissolved in 1:1 methanol-dichloromethane and filtered. The filtrate was concentrated in vacuo and the residue was subjected to radial chromatography on a 2 mm chromatotron plate. These procedures afforded 120 mg(80%) of the title compound as awhite solid. Mass Spectrum (EI): m/z 363, 291, 276, 250, 217, 207, 191, 179, 163, 148, 135, 123, 85, 56.

1. concentrationThe mixture was concentrated in vacuo
2. dissolutiondissolved in 1:1 methanol-dichloromethane
3. filtrationfiltered
4. concentrationThe filtrate was concentrated in vacuo