HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → HCID 10539671, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Methylparaben | HCID 7456 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | Imidazolate | HCID 3386966 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10539671 | HCID 10539671 | — |
Reaction Steps
Methyl 4-hydroxybenzoate was reacted with 1-bromo-2-methoxyethane, and potassium carbonate in dimethylformamide. The resultant ester was hydrolyzed to the acid with NaOH in alcohol. This acid was reacted with carbonyl diimidazole in THF; the resulting imidazolide was reacted with the potassium salt of the mono ethyl ester of malonic acid, and magnesium chloride, to give the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124341 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-8cd06e5acbd84fdc842e6ba06a7d20ae |
| Source note | uspto-grants-2000_09 |