Ammonia → HCID 10902369, compound

Participants

Reaction Conditions

Reaction Steps

In a four-necked flask equipped with a stirrer, a thermometer and a condenser, dissolved 18.4 g (0.1 mol) of cyanuric chloride and 50 ml of acetonitrile were dissolved at room temperatures while stirring, followed by cooling a system and adding dropwise a mixture containing 35 g of an ion-exchanged water, 9.9 g (0.1 mol) of cyclohexyl amine, and 10.1 g (0.1 mol) of triethyl amine over 2 hours while maintaining at a reaction temperature of not more than 5° C. After further stirring at 5° C. for 2 hours, 70 ml of 28% aqueous ammonia of was added dropwise, followed by stirring at 5° C. for 1 hour, at 20° C. for 1 hour, and at 50° C. for 2 hours. After that, temperature was elevated to 60° C., and 54.5 g (0.55 mol) of cyclohexyl amine was added and, further, the temperature was elevated to 70° C., followed by stirring for 3 hours. 180 g of an ion-exchanged water was added dropwise, followed by cooling to 10° C. while stirring. A crystal deposited was filtered and washed with a large quantity of an ion-exchanged water, followed by drying in vacuo to obtain 16.5 g of 2-amino-4,6-bis(monocyclohexyl-amino)-1,3,5-triazine which is in powder-state.

Provenance & Evidence