Potassium Carbonate → HCID 15895341, compound

Participants

Reaction Steps

A mixture of 3-phenoxypropyl bromide (224 mg, 1.04 mmol), 4-phenylpiperidine (140 mg, 0.870 mmol) and K2CO3 (264 mg, 1.91 mmol) in 15 mL of EtOH was refluxed under N2 for 12 hr. The inorganic salt was removed through a short column of silica gel and washed with EtOAc (3×15 mL). The filtrate was evaporated in vacuo to give a residue, which was purified by flash chromatography giving the title as a pale yellow oil (165 mg, 64%): 1H NMR (CDCl3) 1.90 (m, 4 H), 2.10 (m, 4 H), 2.55 (m, 1H), 2.70 (bs, 2 H), 3.20 (bs, 2 H), 4.05 (m, 2 H), 6.92 (m, 4 H), 7.29 (m, 6 H).

Provenance & Evidence