HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 23294523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzene, (3-bromopropoxy)- | HCID 68522 | — |
| Reactant | 1,3-Dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one | HCID 88638 | — |
| Product | HCID 23294523 | HCID 23294523 | 54.4% |
Reaction Steps
A mixture of 4-(2-keto-1-benzimidazolinyl)piperidine (980 mg. 4.51 mmol) and 3-phenoxypropyl bromide (1.02 g, 4.73 mmol) was reacted in the presence of K2CO3 in CH2CN by refluxing under N2 for about 4 h to obtain the hydrobromide as a pale beige solid (1.06 g, 54%); mp 136-138° C. (foams); 1H NMR (CD3OD) δ 2.12 (d, J=13 Hz, 2H), 2.25-2.40 (m, 2 H), 2.81-2.99 (m, 2 H), 3.22-3.49 (m, 4 H), 3.82 (d, J=12 Hz, 2 H), 4.14 (t, J=8.4 Hz, 2 H), 4.55-4.70 (m, 1 H), 6.91-7.41 (m, 9 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124323 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-973821d0e2664a31922dc20057c61515 |
| Source note | uspto-grants-2000_09 |