Potassium Carbonate → 1-[2-(4-Hydroxyphenoxy)ethyl]-4-(2-fluorobenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 2-(4-benzyloxyphenoxy)ethyl bromide (0.393 g, 1.28 mmol), 4-(2-fluorobenzyl)piperidine hydrochloride (0.294 g, 1.28 mmol) and potassium carbonate (0.442 g, 3.2 mmol) in two steps as an off white solid (0.237 g), mp 196-198° C. 1H NMR (CD3OD) 1.629 (m, 2 H), 1.900 (m, 3 H), 2.704 (m, 2 H), 3.052 (m, 2 H), 3.500 (m, 2 H), 3.612 (m, 2 H), 4.252 (m, 2 H), 6.703 (d, J=9. 0 Hz, 2 H), 6.825 (6, J=9.0 Hz, 2 H), 7.057-7.248 (m, 2 H), 7.248 (m, 2 H). Anal. Calcd for C20H25ClFNO2.1.2H2O: C, 61.70; H, 7.15; N, 3.60. Found: C, 61.45; H, 6.90; N, 3.53.

Provenance & Evidence