HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 23294526, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Bromoethoxy)-4-methoxybenzene | HCID 579814 | — |
| Reactant | 4-Phenylpiperidine-4-carbonitrile hydrochloride | HCID 3084973 | — |
| Product | HCID 23294526 | HCID 23294526 | — |
Reaction Steps
The title compound was prepared from 4-cyano-4-phenylpiperidine hydrochloride (600 mg, 2.69 mmol), 2-(4-methoxyphenoxy)ethyl bromide (653 mg, 2.82 mmol) and K2CO3 (761 mg, 5.51 mmol) in two steps as a colorless solid (28 mg, 60%), mp 199-200° C.; 1H NMR (CD3OD) 2.48-2.64 (m, 4H), 3.48-3.64 (m, 2H), 3.73 (t, J=4.8 Hz, 2H), 3.95 (d, J=12 Hz, 2H), 4.36 (t, J=4.5 Hz, 2H), 6.74 (d, J=8.7 Hz, 2H), 6.90 (d, J=9.0 Hz, 2H), 7.38-7.64 (m, 5H); HRMS calcd for C20H22N2O2 322.1681, found 322.1678.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124323 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-50290da96ba34dbba5214ad0fa2bfe7b |
| Source note | uspto-grants-2000_09 |