4-Piperidinecarboxamide → HCID 131722011, compound

Participants

Reaction Steps

The title compound was prepared from isonipecotamide, 2-(4-fluorophenoxy)ethyl bromide, and K2CO3 in four steps as a pale yellow solid, mp 114-115° C.; 1H NMR (CDCl3) 1.56-1.75 (m, 2H), 1.94 (d, J=15 Hz, 2H), 2.08-2.25 (m, 1H), 2.96-3.18 (m, 4H), 3.33-3.56 (m, 2H), 3.62-3.73 (m, 2H), 4.32 (d, J=4.8 Hz, 2H), 6.26 (s, 4H), 6.91-7.12 (m, 4H), 7.84-7.94 (m, 2H), 8.48 (td, J=7.8 and 1.5 Hz, 1H), 8.63 (d, J=6.0 Hz, 1H); Anal. Calcd for C27H31FN2O9 : C, 59.33; H, 5.71; N, 5.12. Found: C, 59.36; H, 5.68; N, 4.94.

Provenance & Evidence