Sodium Bicarbonate → HCID 70081424, compound

Participants

Reaction Steps

The title compound was prepared from 4-((5,6,7,8-tetrahydro-2-naphthyl)methyl)piperidine hydrochloride (250 mg, 940 μmol), 2-(4-hydroxyphenoxy)ethyl bromide (204 mg, 940 μmol) and NaHCO3 (162 mg, 1.93 mmol) as a pale beige solid (152 mg): 1H NMR (CD3OD) 1.55-1.65 (m, 2H), 1.70-1.96 (m, 7H), 2.54 (d, J=6.3 Hz, 2H), 2.62-2.78 (m, 4H), 3.05 (t, J=12 Hz, 2H), 3.43-3.68 (m, 4H), 4.25 (t, J=4.8 Hz, 2H), 6.72 (d, J=9.0 Hz, 2H), 6.80-6.90 (m, 4H), 6.95 (d, J=7.5 Hz, 1H); Anal. Calcd for C24H32ClNO2 ·H2O: C, 68.64; H, 8.16; N, 3.33. Found: C, 68.39; H, 7.99; N, 3.36.

Provenance & Evidence