Sodium Bicarbonate → HCID 23294282, compound

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Reaction Steps

The title compound was prepared from 4-((2-naphthyl)methyl)piperidine hydrochloride (150 mg, 573 μmol), 2-(4-hydroxyphenoxy)ethyl bromide (130 mg, 602 μmol) and NaHCO3 (97 mg, 1.17 mmol) as a pale yellow solid (182 mg): mp 221-222° C.; 1H NMR (CD3OD) 1.53-1.72 (m, 2H), 1.87-2.12 (m, 3H), 2.81 (d, J=6.9 Hz, 2H), 2.92-3.18 (m, 2H), 3.43-3.70 (m, 4H), 4.25 (t, J=4.8 Hz, 2H), 6.73 (d, J=9.3 Hz, 2H), 6.85 (d, J=9.3 Hz, 2H), 7.32-7.49 (m, 3H), 7.66 (s, 1H), 7.76-7.85 (m, 3H); Anal. Calcd for C24H28ClNO2 ·0.4H2O: C, 71.15; H, 7.16; N, 3.46. Found: C, 71.17; H. 6.80; N, 3.11.

Provenance & Evidence