Potassium Carbonate → HCID 23294509, compound

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Reaction Steps

The title compound was prepared from 4-((2-naphthyl)methyl)piperidine hydrochloride (150 mg, 573 μmol), 2-(4-fluorophenoxy)ethyl bromide (132 mg, 602 μmol) and K2CO3 (162 mg, 1.17 mmol) as a colorless solid (126 mg): mp 170-172° C.; 1H NMR (CDCl3) 1.60-1.92 (m, 3H), 2.02-2.41 (m, 2H), 2.65-2.90 (m, 4H), 3.45-3.55 (m, 2H), 3.60-3.71 (m, 2H), 4.51 (t, J=4.2 Hz, 2H), 6.77-7.01 (m, 4H), 7.25 (d, J=6.0 Hz, 1H), 7.40-7.51 (m, 2H), 7.57 (s, 1H), 7.72-7.84 (m, 3H) 12.64 (bs, 1H). Anal. Calcd for C24H27ClFNO: C, 72.08; H, 6.80; N, 3.50. Found: C, 71.73; H, 6.64; N, 3.34.

Provenance & Evidence