Potassium Carbonate → 1-[2-(4-Hydroxy-3-methylphenoxy)ethyl]-4-(2-fluoro-4-methylbenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(2-fluoro-4-methylbenzyl)piperidine hydrochloride (311.7 mg, 1.28 mmol), 2-(4-benzyloxy-3-methylphenoxy)ethyl bromide (411 mg, 1.28 mmol) and potassium carbonate (444 mg, 3.2 mmol) in two steps as white-off solid (244 mg), mp 165-167° C. 1H NMR (CD3OD) 1.503 (m, 2 H), 1.848 (m, 3 H), 2.076 (s, 3 H), 2.223 (s, 3 H), 2.560 (m, 2 H), 2.932 (m, 2 H), 3.389 (m, 2 H), 3.526 (m, 2 H), 4.141 (t, J=5.1 Hz, 2 H), 6.758 (s, 1 H), 6.667 (s, 1 H), 6.788-6.858 (m, 3 H), 7.109 (m, 1 H). Anal. Calcd for C22H29ClFNO2 : C, 67.08; H, 7.42; N, 3.98. Found: C, 66.85; H, 7.44; N, 3.46.

Provenance & Evidence