Potassium Carbonate → 1-[2-(4-Hydroxy-3-fluorophenoxy)ethyl]-4-(2-fluoro-4-methylbenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(2-fluoro-4-methylbenzyl)piperidine hydrochloride (311.7 mg, 1.28 mmol), 2-(4-benzoxy-3-fluorophenoxy)ethyl bromide (411 mg, 1.28 mmol), potassium carbonate (444 mg, 3.2 mmol) in two steps as white-off solid (270 mg), mp 128-130° C. 1H NMR (CD3OD) 1.40 (m, 2 H), 1.704 (m, 3 H), 2.114 (s, 3 H), 2.422 (d, J=6.3 Hz, 2 H), 2.837 (m, 2 H), 3.303 (m, 2 H), 3.430 (d, J=11.4 Hz, 2 H), 4.072 (m, 2 H), 6.50 (m, 1 H), 6.632-6.750 (m, 4 H), 6.90 (m, 1 H). Anal. Calcd for C21H26ClF2NO2.0.4H2O: C, 62.25; H, 6.67; N, 3.46. Found: C, 62.20; H, 6.61; N, 3.22.

Provenance & Evidence