Potassium Carbonate → 1-[2-(4-Hydroxy-3-fluorophenoxy)ethyl]-4-(4-fluorobenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(4-fluorobenzyl)piperidine hydrochloride (344 mg, 1.50 mmol), 2-(4-benzoxy-3-fluorophenoxy)ethyl bromide (487 mg, 1.50 mmol), potassium carbonate (518 mg, 3.75 mmol) in two steps as white-off solid (277 mg), mp 184-186° C. 1H NMR (CD3OD) 1.40 (m, 2 H), 1.709 (m, 3 H), 2.424 (d, J=4.8 Hz, 2 H), 2.850 (m, 2 H), 3.319 (m, 2 H), 3.443 (d, J=12.0 Hz, 2 H), 4.087 (s, 2 H), 6.50 (m, 1 H), 6.642 (m, 2 H), 6.833 (m, 2 H), 7.021 (m, 2 H).

Provenance & Evidence