Potassium Carbonate → 1-[2-(4-Hydroxy-3-methylphenoxy)ethyl]-4-(4-fluorobenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(4-fluorobenzyl)piperidine hydrochloride (344 mg, 1.5 mmol), 2-(4-benzoxy-3-methylphenoxy)ethyl bromide (482 mg, 1.5 mmol) and potassium carbonate (518 mg, 3.8 mmol) in two steps as white-off solid (240 mg): mp 118-120° C. 1H NMR (CD3OD) 1.40 (m, 2 H), 1.699 (m, 3 H), 1.975 (s, 3 H), 2.441 (t, 2 H), 2.82 (m, 2 H), 3.310 (m, 2 H), 3.45 (m, 2 H), 4.054 (s, 2 H), 6.481 (s, 2 H), 6.753 (s, 1 H), 6.83 (m, 2 H), 7.021 (m, 2 H). Anal. Calcd for C21H27ClFNO2.0.7H2O: C, 64.25; H, 7.29; N, 3.57. Found: C, 64.24; H, 7.02; N, 3.91.

Provenance & Evidence