Potassium Carbonate → 1-[2-(4-Hydroxy-3-methylphenoxy)ethyl]-4-hydroxy-4-(4-methylbenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 2-(4-benzyloxy-3-methylphenoxy)ethyl bromide (385 mg, 1.2 mmol), 4-(4-ethylbenzyl)-4-hydroxypiperidine hydrochloride (290 g, 1.2 mmol) and potassium carbonate (414 mg, 3 mmol) in two steps as white solid (200 mg): mp 90-94° C. (dec.). 1H NMR (CD3OD) 1.641 (m, 2 H), 1.859 (m, 2 H), 2.083 (5, 3 H), 2.224 (s, 3 H), 2.718 (s, 2 H), 3.260-3.423 (m, 6 H), 4.133 (m, 2 H), 6.585 (s, 2 H), 6.668 (s, 1 H), 7.035 (m, 4 H).

Provenance & Evidence