Potassium Carbonate → 4-(4-Fluorobenzyl)-1-[2-(3-Hydroxyphenoxy)ethyl]piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(4-fluorobenzyl)piperidine hydrochloride (298 mg, 1.30 mmol), 2-(3-benzyloxyphenoxy)ethyl bromide (399 mg, 1.3 mmol) and potassium carbonate (449 mg, 3.2 mmol) in two steps as white-off solid (250 mg): mp 145-147° C. 1H NMR (CD3OD) 1.529 (m, 2 H), 1.821 (d, J=12.9 Hz, 2 H), 2.551 (d, J=6.3 Hz, 2 H), 3.003 (m, 2 H), 3.468 (m, 2 H), 3.541 (m, 2 H), 4.243 (t, J=5.4 Hz, 2 H), 6.369-6.422 (m, 3 H), 6.924-7.034 (m, 3 H), 7.120-7.167 (m, 2 H).

Provenance & Evidence