Hydrochloric Acid → HCID 131722012, compound

Participants

Reaction Steps

The title compound was prepared from 4-(4-fluorobenzyl)piperidine (from 804 mg of the hydrochloride), 4-hydroxythiophenoxyacetaldehyde (560 mg, 3.33 mmol) and NaCNH3B (416 mg, 6.66 mmol) in MeOH (100 mL) as a colorless crystalline solid (430 mg): mp 177-178° C.; 1H NMR (CD3OD) 1.40-1.60 (m, 2H), 1.76-1.92 (m, 3H), 2.59 (d, J=6.3 Hz, 2H), 2.81-3.00 (m, 2H), 3.08-3.26 (m, 4H), 3.42-3.58 (m, 2H), 6.78 (d, J=8.7 Hz, 2H), 6.96-7.22 (m, 4 H), 7.36 (d, J=8.7 Hz, 2H).

Provenance & Evidence