Potassium Carbonate → 1-(2-(4-Chlorophenoxy)ethyl)-4-(4-methylbenzyl)piperidine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(4-methylbenzyl)piperidine hydrochloride (600 mg, 2.66 mmol), 2-(4-chlorophenoxy)ethyl bromide (658 mg, 2.79 mmol) and K2CO3 (754 mg, 5.45 mmol) in CH3CN (50 mL) as colorless flakes (661 mg): mp 201-203° C.; 1H NMR (CDCl3) 1.60-2.12 (m, 5H), 2.31 (s, 3H), 2.58 (d, J=7.2 Hz, 2H), 2.63-2.82 (m, 2H), 3.20-3.50 (m, 2H), 3.58-3.70 (m, 2H), 4.53 (t, J=4.2 Hz, 2H), 6.80 (d, J=9.3 Hz, 2H), 7.00 (d, J=7.5 Hz, 2H), 7.09 (d, J=7.8 Hz, 2H), 7.24 (d, J=8.7 Hz, 2H), 12.60 (b, 1H).

Provenance & Evidence