反应详情

From a mixture of 4-benzylpiperidine (2.68 9, 15.1 mmol), 2-(4-benzyloxy-3-nitrophenoxy)ethyl bromide (2.65 g, 7.52 mmol) and KI (110 mg) in toluene (25 mL) was obtained 2.59 g (77%) of 4-benzyl-1-(2-(4-benzyloxy-3-nitrophenoxy)ethyl)piperidine as an orange-yellow oil. 1H NMR (CDCl3): 1.30-1.42 (m, 2H), 1.50-1.60 (m, 1H), 1.64-1.68 (m, 2H), 2.02-2.10 (m, 2H), 2.547 (d, 2H, J=7), 2.777 (t, 2H, T=6), 2.95-3.00 (m, 2H), 4.085 (t, 2H, J=6), 5.181 (s, 2H), 7.02-7.46 (m, 8H).