4-Benzylpiperidine → HCID 23294266, compound

Participants

Reaction Steps

From a mixture of 4-benzylpiperidine (820 mg, 4.68 mmol), 2-(3-hydroxy-4-nitrophenoxy)ethyl bromide (556 g, 2.26 mmol) and KI (180 mg) in toluene (25 mL) was obtained 750 g (97%) of 4-benzyl-1-(2-(3-hydroxy-4-nitrophenoxy)ethyl)piperidine as a yellow powder, mp. 136-7° C. 1H NMR (CDCl3): 1.28-1.40 (m, 2H), 1.50-1.68 (m, 1H), 2.02-2.10 (m, 2H), 2.545 (d, 2H, J=7), 2.792 (t, 2H, J=6), 2.93-2.97 (m, 2H), 4.151 (t, 2H, J=6), 6.50-6.53 (m, 2H), 7.13-7.31 (m, 5H), 8.027 (d, 1H, J=10).

Provenance & Evidence