反应详情

From a mixture of 4-(4-methylbenzyl)-1-[2-(4-nitrophenoxy)ethyl]piperidine (1.80 g, 5.2 mmol), stannous chloride dihydrate (7.40 g, 32.8 mmol) in EtOH (50 mL) was obtained 1.43 g (84%) of the title compound as a viscous oil. 1H NMR (CDCl3): 1.25-1.38 (m, 2H), 1.36-1.56 (m, 1H), 1.61-1.65 (m, 2H), 1.98-2.05 (m, 2H), 2.315 (s, 3H), 2.490 (d, 2H, J=7), 2.726 (t, 2H, J=6), 2.94-2.98 (m, 2H), 3.316 (bs, 2H), 4.015 (t, 2H, J=6), 6.681 (AB, 2H, J=9), 7.056 (AB, 4H, J=9).