4-Piperidinol, 1-methyl- → HCID 70274348, 화합물

HRID 1955268노트

반응식

HRID 1955268 반응식
[C:1]1([C:7]2([C:11]([Cl:13])=[O:12])[CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14][N:15]1[CH2:20][CH2:19][CH:18]([OH:21])[CH2:17][CH2:16]1>CS(C)=O.C(O)(C(F)(F)F)=O>[ClH:13].[C:1]1([C:7]2([C:11]([O:21][CH:18]3[CH2:19][CH2:20][N:15]([CH3:14])[CH2:16][CH2:17]3)=[O:12])[CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 660484-Piperidinol, 1-methyl-HCID 232948921-Phenylcyclobutanecarbonyl chloride

생성물 1

HCID 70274348HCID 70274348, 화합물

시약·촉매·용매 1

HCID 20405524Dmso tfa용매

실험 절차

The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutanecarbonyl chloride with 1-methyl-4-hydroxypiperidine at 80° C. for 20 h. The yield was 0.77 g (44%); mp 203-206° C.; 1H NMR (DMSO-d6, 1% TFA) δ 1.76 (d, 2H), 1.83 (m, 1H), 1.96 (m, 2H), 2.05 (t, 1H), 2.41-2.51 (m, 2H), 2.53-2.85 (m, 6H), 3.03 (q, 1H), 3.20 (d, 1H), 3.34 (d, 1H), 4.8 (m, 0.4H), 4.93 (m, 0.6H), 7.23-7.40 (m, 5H). Anal. (C17H23NO2.HCl) C, H. N. The compound exists in two forms in DMSO-TFA solution.

후처리

  1. customat 80° C.
  2. customfor 20 h

출처 및 근거

ORD 기록
ord-ab88e7ea7de549dd8b94e56c40b84f89
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06124354

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