8-Methyl-8-azabicyclo(3.2.1)octan-3-ol → HCID 70276397, compound

Participants

Reaction Steps

The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutanecarbonyl chloride with tropine at 80° C. for 22 h. The yield was 0.5 g (28%); mp 181-183° C.; 1H NMR (D2O) δ 1.78 (q, 2H), 1.96 (m, 1H), 2.04 (d, 2H), 2.13 (m, 3H), 2.38 (m, 2H), 2.64 (m, 2H), 2.77 (s, 3H), 2.87 (m, 2H), 3.82 (m, 2H), 5.07 (t, 1H), 7.42 (m, 1H), 7.47 (m, 2H), 7.52 (m, 2H). Anal. (C19H25NO2.HCl) C, H, N.

Provenance & Evidence