(+-)-3-Quinuclidinol → HCID 23294956, compound

Participants

Reaction Steps

The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutancarbonyl chloride with 3-quinuclidinol at 80° C. for 15 h. The yield was 0.4 g (22%); mp 163-168° C.; 1H NMR (D2O) δ 1.80 (m, 2H), 1.88-2.02 (m, 2H), 2.04-2.17 (m, 2H), 2.38 (m, 1H), 2.59-2.70 (m, 2H), 2.90 (m, 2H), 3.08 (q, 1H), 3.18 (d, 1H), 3.28-3.39 (m, 3H), 3.69 (m, 1H), 5.18 (m, 1H), 7.42 (m, 1H), 7.47-7.54 (m, 4H). Anal. (C18H23NO2.HCl.0.5H2O) C, H, N.

Provenance & Evidence