(+-)-3-Quinuclidinol → HCID 23294910, compound

Participants

Reaction Steps

The title compound was prepared in an analogous manner to that in Example 36. 1-(3-Nitrophenyl)cyclobutanecarbonyl chloride, prepared from the compound prepared in Example 33, was reacted with 3-quinuclidinol in CH2Cl2 for 2 h. The crude was chromatographed on silica gel using EtOAc-Et3N 90:10 as eluent. The yield was 0.4 g (26%); mp 191-192° C.; 1H NMR (CD3OD) δ 1.73-2.29 (m, 7H), 2.62 (m, 2H), 2.94 (m, 2H), 3.02-3.36 (m, 5H), 3.65-3.75 (m, 1H), 5.10 (m, 1H), 7.60-7.66 (m, 1H), 7.74-7.78 (m, 1H), 8.13-8.18 (m, 2H). Anal. (C18H22N2O4.HCl) C, H, N.

Provenance & Evidence