Diethylethanolamine → HCID 23294950, compound

Participants

Reaction Steps

1-(2-thienyl)cyclopentanecarboxylic acid (3.1 mmol), prepared in Example 94 above, was refluxed with SOCl2 (0.6 mL) in 4 mL toluene. After 4 h, the reaction mixture was evaporated and the residue was dissolved in toluene. 2-Diethylaminoethanol (9.3 mmol) was added and the mixture was stirred at room temperature overnight. The crude was chromatographed on silica gel using toluene-Et3N 95:5 as eluent. The yield was 0.79 g (76%); mp 122-123° C.; 1H NMR (CDCl3) δ 1.28 (t, 6H), 1.75 (m, 4H), 2.13 (m, 2H), 2.50 (m, 2H), 2.92 (m, 4H), 3.22 (m, 2H), 4.60 (t, 2H), 6.95 (dd, 2H), 7.19 (dd, 1H), 12.4 (br, 1H). Anal. (C16H25NO2S.HCl) C, H, N.

Provenance & Evidence