참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | O-Phenylenediamine | HCID 7243 | — |
| 반응물 | 4,4'-Difluorobenzil | HCID 123072 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2,3-Bis(4-fluorophenyl)quinoxaline | HCID 2260050 | — |
반응 단계
For example, in synthetic route `A2` of FIG. 2, 4,4'-difluorobenzil, 1,2-phenylenediamine and chloroform are charged together in a reaction vessel and stirred. A catalytic amount of trifluoroacetic acid is added slowly and the reaction mixture heated to about 50° C. with continued stirring. After about 16 h, the mixture is cooled to provide 2,3-bis(4-fluorophenyl)quinoxaline after removal of the chloroform. Recrystallization results 2,3-bis(4-fluorophenyl)quinoxaline having a melting point of 127-1290° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06124421 |
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| 출처 데이터셋 | uspto-grants-2000_09 |
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| ORD ID | ord-64a4ef4dedde49bfa63dd084a1b36a6c |
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| 출처 메모 | uspto-grants-2000_09 |
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