Hydrochloric Acid → HCID 54478463, compound

Participants

Reaction Steps

To a suspension of 1-methyl-2-nitroisourea (1.0 g) in a buffer solution of a tris(hydroxymethyl)aminomethanehydrochloric acid (tris-hydrochloric acid buffer solution, 1.0 M, pH: 7.5, 10 ml), methylamine hydrochloride (0.6 g) was added at room temperature. After stirring for 3 hours, an aqueous hydrochloric acid (4 M) was added, and then the solution was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate, and it was then concentrated under reduced pressure. The residual oil was purified with silica gel column chromatography (hexane/ethyl acetate: 2/1) and then recrystallized (ethyl acetate-hexane), to obtain the desired compound (0.8 g) as colorless crystals.

Provenance & Evidence